Community Dental Health (2024) 41, 14–19 Received 3 June 2023; Accepted 14 August 2023 Objective: Individuals with special needs requiring special care are more vulnerable to oral health problems. Sign language is a communication medium and language of instruction for individuals with hearing impairments. The purpose of this systematic review and meta-analysis was to assess the effectiveness of sign language-based educational interventions compared to other educational interventions in improving the oral health of hearing-impaired individuals. Methods: PubMed, Scopus, Embase, and Cochrane Central Register of Controlled Trials databases were searched without any restriction on the publication date. Analytical and experimental studies that evaluated and compared the effectiveness of sign language with other educational intervention groups such as videos, posters etc were included. Results: Initially, 5568 records were identified. Three relevant publications from India were eligible and included in the systematic review and meta-analysis. Differences were reported in favour of sign language over other interventions concerning plaque status, gingival health, and oral hygiene status. Conclusion: Sign language-based interventions were found to be effective. However, further studies in different locations and populations are required to support their effectiveness. Keywords: Oral Health, Oral Hygiene, Persons with hearing impairments